Natural Antisense Transcripts at the Interface between Host Genome and Mobile Genetic Elements
نویسندگان
چکیده
منابع مشابه
Natural Antisense Transcripts at the Interface between Host Genome and Mobile Genetic Elements
Non-coding RNAs are involved in epigenetic processes, playing a role in the regulation of gene expression at the transcriptional and post-transcriptional levels. A particular group of ncRNA are natural antisense transcripts (NATs); these are transcribed in the opposite direction to protein coding transcripts and are widespread in eukaryotes. Their abundance, evidence of phylogenetic conservatio...
متن کاملHuman cis natural antisense transcripts initiated by transposable elements.
The capacity of human transposable elements (TEs) to promote cis natural antisense transcripts (cis-NATs) is revealed by the discovery of 48,718 human gene antisense transcriptional start sites (TSSs) within TE sequences. TSSs that yield cis-NATs are overrepresented among TE sequences, and TE-initiated cis-NATs are more abundant close to the 3' ends of genes. The TE sequences that promote antis...
متن کاملNatural antisense transcripts.
Recent years have seen the increasing understanding of the crucial role of RNA in the functioning of the eukaryotic genome. These discoveries, fueled by the achievements of the FANTOM, and later GENCODE and ENCODE consortia, led to the recognition of the important regulatory roles of natural antisense transcripts (NATs) arising from what was previously thought to be 'junk DNA'. Roughly defined ...
متن کاملGenome-wide view of natural antisense transcripts in Arabidopsis thaliana
Natural antisense transcripts (NATs) are endogenous transcripts that can form double-stranded RNA structures. Many protein-coding genes (PCs) and non-protein-coding genes (NPCs) tend to form cis-NATs and trans-NATs, respectively. In this work, we identified 4,080 cis-NATs and 2,491 trans-NATs genome-widely in Arabidopsis. Of these, 5,385 NAT-siRNAs were detected from the small RNA sequencing da...
متن کاملNATsDB: Natural Antisense Transcripts DataBase
Natural antisense transcripts (NATs) are reverse complementary at least in part to the sequences of other endogenous sense transcripts. Most NATs are transcribed from opposite strands of their sense partners. They regulate sense genes at multiple levels and are implicated in various diseases. Using an improved whole-genome computational pipeline, we identified abundant cis-encoded exon-overlapp...
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ژورنال
عنوان ژورنال: Frontiers in Microbiology
سال: 2017
ISSN: 1664-302X
DOI: 10.3389/fmicb.2017.02292